Insight

Colorectal cancer (CRC) remains a significant global health challenge due to its high incidence and mortality rates. Despite advancements in treatment, identifying patients who could benefit from specific therapies remains challenging. Traditional tissue biopsies have limitations such as spatial and temporal heterogeneity. Liquid biopsy (LB), particularly circulating tumor DNA (ctDNA) analysis, emerges as a promising…

Radiation therapy utilizes high doses of ionizing or particulate radiation to kill cancer cells. It is an integral component of multimodality cancer care. However, the challenge lies in delivering it precisely to the target while sparing surrounding healthy tissues. Technological advancements have revolutionised radiation therapy planning and delivery leaps and bounds. Especially incorporation of axial…

Ovarian cancer, often lurks undetected until its later stages, complicating treatment and diminishing long-term survival rates. Despite its elusive nature, recent advancements in treatment modalities offer a glimmer of hope for those affected by this insidious disease. At the forefront of ovarian cancer treatment is the combination of surgery and chemotherapy. Surgeons meticulously navigate the…

Tuberculosis (TB) persists as a formidable global health concern, necessitating innovative solutions for its diagnosis, treatment, and management. In this relentless battle against TB, bioinformatics emerges as a formidable ally, offering indispensable insights and advancements that transcend traditional research boundaries. Microbiome Analysis and Contaminant Removal: Bioinformatics empowers researchers to delve into the intricate microbial ecosystems…

World Thalassemia Day serves as a reminder of the global burden posed by thalassemias, genetic disorders characterized by impaired production of hemoglobin. While historically managed through transfusions and iron chelation therapy, recent years have witnessed remarkable advancements in treatment modalities, offering hope for improved outcomes and quality of life for patients. One of the most…

Bladder cancer diagnosis has undergone significant advancements, with liquid biopsy emerging as a promising non-invasive approach. This method utilizes urine samples to detect various biomarkers, providing valuable insights into cancer presence, progression, and treatment responses. Liquid biopsy in bladder cancer detection analyzes circulating tumor cells, cell-free DNA, RNA, and proteins in urine, offering a non-invasive…

A well-designed diagnostic gene panel is essential for effectively diagnosing genetic disorders while minimizing unnecessary testing and potential patient anxiety. Such panels should prioritize maximizing clinical sensitivity and specificity while also considering clinical validity and utility. Clinical sensitivity, determined by both biomedical knowledge and technical capabilities, ensures that the panel can accurately detect relevant gene-disease…

Immunotherapy has emerged as a pivotal approach in cancer treatment, leveraging the body’s own immune system to combat the disease. Comprising a diverse range of strategies, immunotherapy targets the mechanisms by which cancer cells evade immune detection and destruction. One such strategy involves immune checkpoint inhibitors, which disrupt the interaction between checkpoint proteins on T…

Cancer remains one of the most challenging diseases to treat, with its complex and heterogeneous nature requiring tailored approaches for optimal management. In this landscape, cytogenetics and Fluorescence In Situ Hybridization (FISH) emerge as indispensable tools, offering profound insights into tumor biology and guiding personalized treatment strategies. Cytogenetics plays a crucial role in cancer diagnosis…

Genetic testing plays a key role in diagnosing and managing inherited cardiac diseases, aiming to pinpoint their underlying causes. By explaining the genetic basis of conditions like long QT syndrome, clinicians can tailor treatment strategies and offer prognostic insights. Even in cases where electrocardiograms appear normal, genetic testing becomes indispensable for accurate diagnosis and risk…