Quest Diagnostics and Scipher Medicine have entered into a collaboration to enhance diagnostic services for individuals with rheumatoid arthritis (RA). The agreement involves Quest providing RNA extraction and next-generation sequencing services for Scipher’s PrismRA test, a blood-based molecular assay designed to predict patient response to TNF inhibitors—a common first-line treatment for RA. Additionally, Quest will handle specimen collection and transport as part of the collaboration. The financial details of the agreement were not disclosed.
TNF inhibitors are not effective in about one-third of RA patients, leading to inefficient healthcare spending and delays in obtaining effective treatment. Scipher, based in Waltham, Massachusetts, profiles approximately two dozen RNAs and combines them with patient data and results from anti-cyclic citrullinated peptide testing to identify individuals unlikely to respond to TNF inhibitor treatment. Quest, based in Marlborough, Massachusetts, will extract and sequence RNA for the PrismRA test at its laboratory.
Mark Gardner, Senior VP of Molecular Genomics and Oncology at Quest, highlighted the collaboration asaligned with Quest’s strategy and investments in genomics, particularly next-generation sequencing, and blood-specimen logistics. This collaboration enables Quest to contribute to the field of precision medicine, benefiting large, underserved patient populations. Scipher Medicine’s CEO, Alif Saleh, expressed excitement about working with Quest Diagnostics, aiming to provide patients access to the PrismRA test through this strategic partnership.