Artificial Intelligence (AI) stands at the forefront of transforming in vitro fertilization (IVF), offering hope to couples on the challenging path to parenthood. With a current success rate of approximately 30%, integrating AI into IVF clinics holds significant promise for improving outcomes. AI’s application in gamete selection eliminates subjectivity, providing rapid and accurate rankings for both female oocytes and male sperm based on quality factors, particularly beneficial for procedures like intracytoplasmic sperm injection (ICSI).
Crucially, AI can enhance embryo selection, traditionally reliant on morphological assessments. By using routinely generated images and time-lapse videos, AI objectively grades and ranks embryos, reducing variability among operators and clinics. This data-driven approach may improve predictions related to pregnancy and live birth outcomes, marking a substantial advancement in reproductive medicine.
AI’s potential extends into the analysis of non-invasive metabolomics and secretory profiles from embryos during culture, potentially leading to advancements in culture media formulations and regimens for optimizing successful embryo development.
Moreover, AI could transform the formulation of patient-specific IVF treatment regimens by considering factors such as patient age, genetic history, gamete quality, and medical history. The data mining of existing patient records using AI opens avenues for discovering novel markers predicting pregnancy and live birth, as seen in other medical fields.
However, challenges in AI integration into IVF clinics exist, including the need for extensive data, potential biases in smaller clinics, and the lack of standardized recording and reporting across institutions. Transparent and interpretable mechanisms are essential to build trust and credibility in clinical settings. Concerns about clinics optimizing practices for AI scores, the necessity for rigorous validation studies, and data security underscore the complex landscape AI must navigate before becoming a routine part of IVF practice.
AI holds immense promise in revolutionizing the future of IVF, offering hope to millions of couples struggling with infertility. By harnessing the power of AI, clinicians can potentially enhance IVF success rates, paving the way for personalized reproductive medicine and improved fertility outcomes. Realizing the full potential of AI in the infertility service requires collaborative efforts, technological advancements, and rigorous validation studies to overcome the challenges ahead, as the demand for IVF continues to rise globally.